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Apple, Eli Lily & Evidation Study use iPhone, iPad and Watch to detect MCI



Apple Inc., Eli Lilly and Company and Evidation Health Inc. teamed up to conduct the successful study on early detection of Measures of Cognitive Impairment (MCI) and dementia using Apple's smartphone, smartwatch, tablet. [19659002Thefollow-upstudytitle: Developing Measures of Cognitive Impairment in the Real World from Consumer-Class Multimodal Sensor Streams around 5.7 million Americans and 46.8 million people worldwide are plagued by dementia costing about $ 1 trillion . Its early detection is considered a clinical challenge and often time consuming.

Dementia is a type of cognitive failure that causes one to forget places, names or events that affect memory and thinking. It is symptomatic in nature, while Alzheimer's is a disease that is degenerative and irreversible. Early symptoms of onset of dementia are subtle, insidious and easily dismissed as " normal aging ."

During the study, the team used the Apple iPhone, Apple Watch and iPad to help monitor patients undergoing the program. 1

23 prospective patients were performed around December 2017 through August 2018, and screened out of the total 138, at 12 centers across the United States.

Each participant was given an Apple portable consumer device and mobile computing platforms such as an iPhone 7 plus (to be used as their primary phone), an Apple Watch Series 2, a 10.5 ″ iPad Pro with a smart keyboard and a Beddit sleep monitoring device along with apps to collect all sensor and app usage events.

In May 2017, Apple had acquired the popular iOS sleep tracking platform and hardware manufacturer Beddit. Thus, Apple devices with this particular sleep monitoring app played a critical role in the successful conduct of this study.

All Apple devices helped researchers monitor their health parameters regularly over a 12-week study period and avoid conventional methods that would have posed serious questions about appropriate monitoring.

The report said: “ In this work, we present a platform for remote and modest monitoring of symptoms related to cognitive failure using multiple smart devices for consumer class. We demonstrate how the platform has been used to collect a total of 16 TB of data during the Lilly Exploratory Digital Assessment Study, a 12-week feasibility study that monitored 31 people with cognitive impairment and 82 without cognitive impairment under free living conditions. ”

Image of end-to-end data flow. Adapted from “Clinical Trials Transformation Initiative (CTTI) Recommendations: Promote the Use of Mobile Technologies for Data Capture and Improved Clinical Studies”. Released July 2018

 iPhone, Apple Watch and iPad used for health monitoring in dementia study

The results of the study pointed to the following:

  • Slower writing: Symptomatic participants had tends to have slower writing than healthy controls. These results are in line with previous work, and perhaps the result of impaired fine motor control, language difficulties or both.
  • Less regularity and later first steps: In general, symptomatic individuals showed less routine behavior compared to healthy controls, which is probably equivalent to picking up the phone for the first time and putting down the phone for the last time each day.
  • Fewer text messages: Symptomatic participants received fewer text messages overall (and per day) and had a lower interquartile range of daily outgoing messages.
  • Greater dependency on help apps: Symptomatic individuals spent more total time in the Clock app than healthy controls and were more likely to see or access Siri's app suggestions.
  • Compliance with inferior surveys: Symptomatic individuals answered the daily one-question surveys less frequently than healthy controls, and when they answered, they tended to respond later in the day.

In a statement to CNBC Evidation co-founder Christine Lemke, said, "With this research, we looked at how everyday behavioral data, such as those captured by iPhones, Apple Watches and Beddit sleep monitors, can be effective in distinguishing between individuals with mild cognitive failure and early Alzheimer's disease, and those without symptoms. "

Apple products that contribute to various studies and health creation of apps for the benefit of users

The above study proves Cupertino major and its products' ability to monitor health and to contribute to human welfare, by the way.

Recently, Apple partnered with Google, Microsoft and the Medicaid agencies for the Carin Blue Button Health App to be available in the United States for trial by the end of the year.

The Apple Watch has proven that it is worth proving to be a savior of a kind by alerting people who suffered irregular heartbeats or discovering a fall or even saving one from drowning.

Medical fraternities may turn to such portable consumer devices and mobile computing platforms to study or monitor the health of patients from remote locations and at any time as researchers found during this study.

Only time will show how invasive or intrusive technology can better monitor vitalities and improve patient care and health to prove that they are worthwhile.


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