Your screen does not indicate anything suspicious.
By default, most Macs will mark the checkbox Use passive FTP mode (PASV) so you need not be concerned about this. 19659002] In addition, most Macs will also have entries like yours in Bypass proxy settings for these host and domain fields .
In a nutshell, if the computer is connected to a network that has a firewall 1 in place, you may need to enter proxy servers 2 and / or select Use passive FTP mode (PASV) to access some websites.
1 A "firewall" is designed to protect computers from unwanted / unauthorized networks / Internet connections
2 A proxy server is a computer on a local network that serves as a middle man between users and the Internet. It is designed to increase security and provide other administrative features.